研究成果
原著
Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus.
Kamatani, T., et al.
Biomaterials, 2022. 284: p. 121491.
Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.
Tam, W.L., et al.
Stem Cell Res Ther, 2021. 12(1): p. 513.
Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface.
Okutani, Y., et al.
Tissue Eng Part A, 2022. 28(1-2): p. 94-106.
Implantation of human iPS cell-derived cartilage in bone defects of mice.
Iimori, Y., Morioka, M., Koyamatsu, S., and Tsumaki, N.
Tissue Eng. Part A 2021
（PMID：33567995 DOI：10.1089/ten.TEA.2020.0346）
Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.
Yamashita, A., Yoshitomi, H., Kihara, S., Toguchida, J., and Tsumaki, N.
Stem Cells Transl. Med. 10(1):115-127 2020
（PMID：32822104 DOI：10.1002/sctm.20-0058）
Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage.
Takei, Y., Morioka, M., Yamashita, A., Kobayashi, T., Shima, N., and Tsumaki, N.
Sci Rep 30;10(1):12794 2020
（PMID：32732907 DOI：10.1038/s41598-020-69641-4）
Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.
Kosai, A., Horike, N., Takei, Y., Yamashita, A., Fujita, K., Kamatani, T., and Tsumaki, N.
Biochem. Biophys. Res. Commun. 516(4):1097-1102 2019
（PMID：31280862 DOI：10.1016/j.bbrc.2019.06.139）
Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface.
Okutani, Y., Abe, K., Yamashita, A., Morioka, M., Matsuda, S., and Tsumaki, N.
Tissue Eng Part A, 28(1-2): p. 94-106, 2022.
Human iPS cell-derived cartilaginous tissue spatially and functionally replaces nucleus pulposus.
Kamatani, T., Hagizawa, H., Yarimitsu, S., Morioka, M., Koyamatsu, S., Sugimoto, M., Kodama, J., Yamane, J., Ishiguro, H., Shichino, S., Abe, K., Fujibuchi, W., Fujie, H., Kaito, T., and Tsumaki, N.
Biomaterials, 284: p. 121491, 2022.
Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells.
Yamashita, A. and Tsumaki, N.
Dev Growth Differ, 63(1): p. 72-81, 2021.
Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects.
Tam, W.L., Freitas Mendes, L., Chen, X., Lesage, R., Van Hoven, I., Leysen, E., Kerckhofs, G., Bosmans, K., Chai, Y.C., Yamashita, A., Tsumaki, N., Geris, L., Roberts, S.J., and Luyten, F.P.
Stem Cell Res Ther, 12(1): p. 513, 2021.
Implantation of Human-Induced Pluripotent Stem Cell-Derived Cartilage in Bone Defects of Mice.
Iimori, Y., Morioka, M., Koyamatsu, S., and Tsumaki, N.
Tissue Eng Part A, 2021.
Culture substrate-associated YAP inactivation underlies chondrogenic differentiation of human induced pluripotent stem cells.
Yamashita, A., Yoshitomi, H., Kihara, S., Toguchida, J., and Tsumaki, N.
Stem Cells Transl Med, 2020.
Quality assessment tests for tumorigenicity of human iPS cell-derived cartilage.
Takei, Y., Morioka, M., Yamashita, A., Kobayashi, T., Shima, N., and Tsumaki, N.
Sci Rep, 10(1): p. 12794, 2020.
Evaluation of FGFR inhibitor ASP5878 as a drug candidate for achondroplasia.
Ozaki, T., Kawamoto, T., Iimori, Y., Takeshita, N., Yamagishi, Y., Nakamura, H., Kamohara, M., Fujita, K., Tanahashi, M., and Tsumaki, N.
Sci Rep, 10(1): p. 20915, 2020.
Visualization of Human Induced Pluripotent Stem Cells-Derived Three-Dimensional Cartilage Tissue by Gelatin Nanospheres.
Murata, Y., Jo, J.I., Yukawa, H., Tsumaki, N., Baba, Y., and Tabata, Y.
Tissue Eng Part C Methods, 26(5): p. 244-252, 2020.
Changes in acetyl-CoA mediate Sik3-induced maturation of chondrocytes in endochondral bone formation.
Kosai, A., Horike, N., Takei, Y., Yamashita, A., Fujita, K., Kamatani, T., and Tsumaki, N.
Biochem Biophys Res Commun, 516(4): p. 1097-1102, 2019.
Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage.
Chen, X., Yamashita, A., Morioka, M., Senba, T., Kamatani, T., Watanabe, A., Kosai, A., and Tsumaki, N.
Tissue Eng Part A, 25(5-6): p. 437-445, 2019.
A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation.
Kobayashi, T., Fujita, K., Kamatani, T., Matsuda, S., and Tsumaki, N.
Biochem Biophys Res Commun, 495(1): p. 1468-1475, 2018.
Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia.
Kimura, T., Ozaki, T., Fujita, K., Yamashita, A., Morioka, M., Ozono, K., and Tsumaki, N.
Osteoarthritis Cartilage, 26(11): p. 1551-1561, 2018.
Loss of Mob1a/b in mice results in chondrodysplasia due to YAP1/TAZ-TEAD-dependent repression of SOX9.
Goto, H., Nishio, M., To, Y., Oishi, T., Miyachi, Y., Maehama, T., Nishina, H., Akiyama, H., Mak, T.W., Makii, Y., Saito, T., Yasoda, A., Tsumaki, N., and Suzuki, A.
Development, 145(6), 2018.
A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain.
Makino, H., Seki, S., Yahara, Y., Shiozawa, S., Aikawa, Y., Motomura, H., Nogami, M., Watanabe, K., Sainoh, T., Ito, H., Tsumaki, N., Kawaguchi, Y., Yamazaki, M., and Kimura, T.
Sci Rep, 7(1): p. 16983, 2017.
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
Yahara, Y., Takemori, H., Okada, M., Kosai, A., Yamashita, A., Kobayashi, T., Fujita, K., Itoh, Y., Nakamura, M., Fuchino, H., Kawahara, N., Fukui, N., Watanabe, A., Kimura, T., and Tsumaki, N.
Nat Commun, 7: p. 10959, 2016.
Limited Immunogenicity of Human Induced Pluripotent Stem Cell-Derived Cartilages.
Kimura, T., Yamashita, A., Ozono, K., and Tsumaki, N.
Tissue Eng Part A, 22(23-24): p. 1367-1375, 2016.
Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs.
Yamashita, A., Morioka, M., Yahara, Y., Okada, M., Kobayashi, T., Kuriyama, S., Matsuda, S., and Tsumaki, N.
Stem Cell Reports, 4(3): p. 404-418, 2015.
Modeling type II collagenopathy skeletal dysplasia by directed conversion and induced pluripotent stem cells.
Okada, M., Ikegawa, S., Morioka, M., Yamashita, A., Saito, A., Sawai, H., Murotsuki, J., Ohashi, H., Okamoto, T., Nishimura, G., Imaizumi, K., and Tsumaki, N.
Hum Mol Genet, 24(2): p. 299-313, 2015.
Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes.
Itoh, Y., Sanosaka, M., Fuchino, H., Yahara, Y., Kumagai, A., Takemoto, D., Kagawa, M., Doi, J., Ohta, M., Tsumaki, N., Kawahara, N., and Takemori, H.
J Biol Chem, 290(29): p. 17879-17893, 2015.
Statin treatment rescues FGFR3 skeletal dysplasia phenotypes.
Yamashita, A., Morioka, M., Kishi, H., Kimura, T., Yahara, Y., Okada, M., Fujita, K., Sawai, H., Ikegawa, S., and Tsumaki, N.
Nature, 513(7519): p. 507-511, 2014.
Sox9 reprogrammed dermal fibroblasts undergo hypertrophic differentiation in vitro and trigger endochondral ossification in vivo.
Tam, W.L., Dorien, F.O., Hiramatsu, K., Tsumaki, N., Luyten, F.P., and Roberts, S.J.
Cell Reprogram, 16(1): p. 29-39, 2014.
Cartilage intermediate layer protein promotes lumbar disc degeneration.
Seki, S., Tsumaki, N., Motomura, H., Nogami, M., Kawaguchi, Y., Hori, T., Suzuki, K., Yahara, Y., Higashimoto, M., Oya, T., Ikegawa, S., and Kimura, T.
Biochem Biophys Res Commun, 446(4): p. 876-881, 2014.
Cyp26b1 within the growth plate regulates bone growth in juvenile mice.
Minegishi, Y., Sakai, Y., Yahara, Y., Akiyama, H., Yoshikawa, H., Hosokawa, K., and Tsumaki, N.
Biochem Biophys Res Commun, 454(1): p. 12-18, 2014.
Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors.
Outani, H., Okada, M., Yamashita, A., Nakagawa, K., Yoshikawa, H., and Tsumaki, N.
PLoS One, 8(10): p. e77365, 2013.
Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters.日
Minegishi, Y., Hosokawa, K., and Tsumaki, N.
Osteoarthritis Cartilage, 21(12): p. 1968-1975, 2013.
Involvement of SIK3 in glucose and lipid homeostasis in mice.
Uebi, T., Itoh, Y., Hatano, O., Kumagai, A., Sanosaka, M., Sasaki, T., Sasagawa, S., Doi, J., Tatsumi, K., Mitamura, K., Morii, E., Aozasa, K., Kawamura, T., Okumura, M., Nakae, J., Takikawa, H., Fukusato, T., Koura, M., Nish, M., Hamsten, A., Silveira, A., Bertorello, A.M., Kitagawa, K., Nagaoka, Y., Kawahara, H., Tomonaga, T., Naka, T., Ikegawa, S., Tsumaki, N., Matsuda, J., and Takemori, H.
PLoS One, 7(5): p. e37803, 2012.
SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.
Sasagawa, S., Takemori, H., Uebi, T., Ikegami, D., Hiramatsu, K., Ikegawa, S., Yoshikawa, H., and Tsumaki, N.
Development, 139(6): p. 1153-1163, 2012.
Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification.
Nishimura, R., Wakabayashi, M., Hata, K., Matsubara, T., Honma, S., Wakisaka, S., Kiyonari, H., Shioi, G., Yamaguchi, A., Tsumaki, N., Akiyama, H., and Yoneda, T.
J Biol Chem, 287(40): p. 33179-33190, 2012.
An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene.
Higuchi, C., Tsumaki, N., Yoshikawa, H., Sakai, N., Michigami, T., and Ozono, K.
PLoS One, 7(8): p. e42180, 2012.
Induction of chondrogenic cells from dermal fibroblast culture by defined factors does not involve a pluripotent state.
Outani, H., Okada, M., Hiramatsu, K., Yoshikawa, H., and Tsumaki, N.
Biochem Biophys Res Commun, 411(3): p. 607-612, 2011.
Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice.
Okamoto, M., Murai, J., Imai, Y., Ikegami, D., Kamiya, N., Kato, S., Mishina, Y., Yoshikawa, H., and Tsumaki, N.
J Bone Miner Res, 26(10): p. 2511-2522, 2011.
Generation of Monkey Induced Pluripotent Stem Cell-Derived Cartilage Lacking Major Histocompatibility Complex Class I Molecules on the Cell Surface.
Nakamura, Y., Yamamoto, K., He, X., Otsuki, B., Kim, Y., Murao, H., Soeda, T., Tsumaki, N., Deng, J.M., Zhang, Z., Behringer, R.R., Crombrugghe, B., Postlethwait, J.H., Warman, M.L., Nakamura, T., and Akiyama, H.
Nat Commun, 2: p. 251, 2011.
Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage.
Ikegami, D., Iwai, T., Ryo, S., Gu, N., Sugiyama, T., Oh, I., Yoshikawa, H., and Tsumaki, N.
Osteoarthritis Cartilage, 19(2): p. 233-241, 2011.
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways.
Ikegami, D., Akiyama, H., Suzuki, A., Nakamura, T., Nakano, T., Yoshikawa, H., and Tsumaki, N.
Development, 138(8): p. 1507-1519, 2011.
Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors.
Hiramatsu, K., Sasagawa, S., Outani, H., Nakagawa, K., Yoshikawa, H., and Tsumaki, N.
J Clin Invest, 121(2): p. 640-657, 2011.
Expression of dominant negative TGF-beta receptors inhibits cartilage formation in conditional transgenic mice.
Hiramatsu, K., Iwai, T., Yoshikawa, H., and Tsumaki, N.
J Bone Miner Metab, 29(4): p. 493-500, 2011.
Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.
Suzuki, D., Yamada, A., Amano, T., Yasuhara, R., Kimura, A., Sakahara, M., Tsumaki, N., Takeda, S., Tamura, M., Nakamura, M., Wada, N., Nohno, T., Shiroishi, T., Aiba, A., and Kamijo, R.
Dev Biol, 335(2): p. 396-406, 2009.
Characteristics of fracture and related factors in patients with rheumatoid arthritis.
Nampei, A., Hashimoto, J., Koyanagi, J., Ono, T., Hashimoto, H., Tsumaki, N., Tomita, T., Sugamoto, K., Nishimoto, N., Ochi, T., and Yoshikawa, H.
Mod Rheumatol, 18(2): p. 170-176, 2008.
Insulation of the ubiquitous Rxrb promoter from the cartilage-specific adjacent gene, Col11a2.
Murai, J., Ikegami, D., Okamoto, M., Yoshikawa, H., and Tsumaki, N.
Journal of Biological Chemistry, 283(41): p. 27677-27687, 2008.
Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways.
Iwai, T., Murai, J., Yoshikawa, H., and Tsumaki, N.
J Biol Chem, 283(40): p. 27154-27164, 2008.
Hyaline cartilage formation and enchondral ossification modeled with KUM5 and OP9 chondroblasts.
Sugiki, T., Uyama, T., Toyoda, M., Morioka, H., Kume, S., Miyado, K., Matsumoto, K., Saito, H., Tsumaki, N., Takahashi, Y., Toyama, Y., and Umezawa, A.
J Cell Biochem, 100(5): p. 1240-1254, 2007.
Low-intensity pulsed ultrasound increases bone ingrowth into porous hydroxyapatite ceramic.
Iwai, T., Harada, Y., Imura, K., Iwabuchi, S., Murai, J., Hiramatsu, K., Myoui, A., Yoshikawa, H., and Tsumaki, N.
Journal of bone and mineral metabolism, 25: p. 392-399, 2007.
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development.
Okamoto, M., Murai, J., Yoshikawa, H., and Tsumaki, N.
J Bone Miner Res, 21(7): p. 1022-1033, 2006.
Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification.
Hirao, M., Tamai, N., Tsumaki, N., Yoshikawa, H., and Myoui, A.
J Biol Chem, 281(41): p. 31079-31092, 2006.
Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasis.
Tsumaki, N., Kakiuchi, M., Sasaki, J., Ochi, T., and Yoshikawa, H.
J Bone Joint Surg Am, 86-A(11): p. 2399-2405, 2004.
Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow.
Katayama, R., Wakitani, S., Tsumaki, N., Morita, Y., Matsushita, I., Gejo, R., and Kimura, T.
Rheumatology, 43(8): p. 980-985, 2004.
Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia.
Horiki, M., Imamura, T., Okamoto, M., Hayashi, M., Murai, J., Myoui, A., Ochi, T., Miyazono, K., Yoshikawa, H., and Tsumaki, N.
J Cell Biol, 165(3): p. 433-445, 2004.
COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG.
Matsui, Y., Chansky, H.A., Barahmand-Pour, F., Zielinska-Kwiatkowska, A., Tsumaki, N., Myoui, A., Yoshikawa, H., Yang, L., and Eyre, D.R.
Journal of Biological Chemistry, 278(13): p. 11369-11375, 2003.
Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.
Tsumaki, N., Nakase, T., Miyaji, T., Kakiuchi, M., Kimura, T., Ochi, T., and Yoshikawa, H.
J Bone Miner Res, 17(5): p. 898-906, 2002.
Activation of cartilage-derived morphogenetic protein-1 in torn rotator cuff.
Nakase, T., Sugamoto, K., Miyamoto, T., Tsumaki, N., Luyten, F.P., Inui, H., Myoui, A., Tomita, T., and Yoshikawa, H.
Clin Orthop Relat Res, (399): p. 140-145, 2002.
Differential expression of aggrecan mRNA isoforms by chondrosarcoma cells.
Matsui, Y., Araki, N., Tsuboi, H., Tsumaki, N., Nakata, K., Kawabata, H., Eyre, D.R., and Yoshikawa, H.
Anticancer Research, 22(6C): p. 4169-4172, 2002.
Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum.
Nakase, T., Ariga, K., Yonenobu, K., Tsumaki, N., Luyten, F.P., Mukai, Y., Sato, I., and Yoshikawa, H.
European Spine Journal, 10(4): p. 289-294, 2001.
Alternative splicing of fibronectin transcripts in osteochondrogenic tumors.
Matsui, Y., Nakata, K., Araki, N., Ozono, K., Fujita, Y., Tsumaki, N., Kawabata, H., Yasui, N., Sekiguchi, K., and Yoshikawa, H.
Anticancer Research, 21(2A): p. 1103-1106, 2001.
A novel type X collagen gene mutation (G595R) associated with Schmid-type metaphyseal chondrodysplasia.
Matsui, Y., Yasui, N., Kawabata, H., Ozono, K., Nakata, K., Mizushima, T., Tsumaki, N., Kataoka, E., Fujita, Y., and Ochi, T.
Journal of Human Genetics, 45(2): p. 105-108, 2000.
Identification of an enhancer sequence within the first intron required for cartilage-specific transcription of the alpha2(XI) collagen gene.
Liu, Y., Li, H., Tanaka, K., Tsumaki, N., and Yamada, Y.
J Biol Chem, 275(17): p. 12712-12718, 2000.
Role of CDMP-1 in skeletal morphogenesis: promotion of mesenchymal cell recruitment and chondrocyte differentiation.
Tsumaki, N., Tanaka, K., Arikawa-Hirasawa, E., Nakase, T., Kimura, T., Thomas, J.T., Ochi, T., Luyten, F.P., and Yamada, Y.
J Cell Biol, 144(1): p. 161-173, 1999.
Modular arrangement of cartilage- and neural tissue-specific cis-elements in the mouse alpha2(XI) collagen promoter.
Tsumaki, N., Kimura, T., Tanaka, K., Kimura, J.H., Ochi, T., and Yamada, Y.
J Biol Chem, 273(36): p. 22861-22864, 1998.
Differential in situ expression of alpha2(XI) collagen mRNA isoforms in the developing mouse.
Sugimoto, M., Kimura, T., Tsumaki, N., Matsui, Y., Nakata, K., Kawahata, H., Yasui, N., Kitamura, Y., Nomura, S., and Ochi, T.
Cell Tissue Res, 292(2): p. 325-332, 1998.
Genotype phenotype correlation in achondroplasia and hypochondroplasia.
Matsui, Y., Yasui, N., Kimura, T., Tsumaki, N., Kawabata, H., and Ochi, T.
Journal of Bone and Joint Surgery. British Volume, 80(6): p. 1052-1056, 1998.
Splicing patterns of type XI collagen transcripts act as molecular markers for osteochondrogenic tumors.
Matsui, Y., Kimura, T., Tsumaki, N., Nakata, K., Yasui, N., Araki, N., Hashimoto, N., Uchida, A., and Ochi, T.
Cancer Letters, 124(2): p. 143-148, 1998.
Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage.
Tsumaki, N., Kimura, T., Matsui, Y., Nakata, K., and Ochi, T.
J Cell Biol, 134(6): p. 1573-1582, 1996.
A recurrent 1992delCT mutation of the type X collagen gene in a Japanese patient with Schmid metaphyseal chondrodysplasia.
Matsui, Y., Kimura, T., Tsumaki, N., Yasui, N., and Ochi, T.
Japanese Journal of Human Genetics, 41(3): p. 339-342, 1996.
Progressive degeneration of articular cartilage and intervertebral discs. An experimental study in transgenic mice bearing a type IX collagen mutation.
Kimura, T., Nakata, K., Tsumaki, N., Miyamoto, S., Matsui, Y., Ebara, S., and Ochi, T.
International Orthopaedics, 20(3): p. 177-181, 1996.
Cervical spondylotic radiculopathy involving two adjacent nerve roots. Anterior decompression through a single level intervertebral approach.
Iwasaki, M., Okada, K., Tsumaki, N., Obata, H., Shirasaki, N., and Oka, S.
International Orthopaedics, 20(3): p. 137-141, 1996.
Differential expression of an acidic domain in the amino-terminal propeptide of mouse pro-alpha 2(XI) collagen by complex alternative splicing.
Tsumaki, N. and Kimura, T.
J Biol Chem, 270(5): p. 2372-2378, 1995.
著書
Chapter 6 Cartilage Regeneration Using Induced Pluripotent Stem Cell Technologies, In A Tissue Regeneration Approach to Bone and Cartilage Repair
Tsumaki N.
2015, Hala Zreiqat, Vicki Rosen, Colin Dunstan (eds.) Springer International Publishing Switzerland
Chapter 14 Bone Biology: Development and Regeneration Mechanisms, in Physiological and Pathological Conditions, In Strategies in Regenerative Medicine
Yoshikawa H, Tsumaki N., Myoui A
2009, Matteo Santin editor, Springer, ISBN 978-0-387-74659-3
Enhancer analysis of the a1(II) and a2(XI) collagen genes in transfected chondrocytes and transgenic mice.
Tsumaki N., Liu Y, Yamada Y, and Krebsbach P
In Streuli, C. H., and Grant, M. E. (eds.) Extracellular Matrix Protocols, Methods Mol Biol, 139, Humana press, Totowa, NJ, USA, pp. 187-195, 2000.
Altered chondrocyte gene expression in articular cartilage matrix components and susceptibility to cartilage destruction.
Kimura T, Nakata K, Tsumaki N., Ono K
In Mow, V.C. (Ed.) Cell Mechanics and Cellular Engineering, Springer-Verlag, New York, USA, pp. 445-456, 1994.
総説
Recent progress of animal transplantation studies for treating articular cartilage damage using pluripotent stem cells.
Yamashita, A. and N. Tsumaki
Dev Growth Differ, 2021. 63(1): p. 72-81.
Considerations in hiPSC-derived cartilage for articular cartilage repair.
Yamashita, A., Tamamura, Y., Morioka, M., Karagiannis, P., Shima, N., and Tsumaki, N.
Inflamm Regen, 38: p. 17, 2018.
iPS cell technologies and cartilage regeneration.
Tsumaki, N., Okada, M., and Yamashita, A.
Bone, 70: p. 48-54, 2015.
Cell reprogramming for skeletal dysplasia drug repositioning.
Karagiannis, P. and Tsumaki, N.
Cell Cycle, 13(24): p. 3791-3792, 2014.
The role of bone morphogenetic proteins in endochondral bone formation.
Tsumaki, N. and Yoshikawa, H.
Cytokine Growth Factor Rev, 16(3): p. 279-285, 2005.